A full list of Publications can be found here Recent Publications Validation of a multiplex microsphere immunoassay for detection of antibodies to Trypanosoma cruzi in dogs Carlos A Rodriguez, Rachel E Busselman, Huifeng Shen, Ashley B Saunders, Rick Tarleton, Sarah A Hamer. J Vet Diagn Invest. 2023 Sep 5;10406387231198525. doi: 10.1177/10406387231198525. cGAS–STING Pathway Activation during Trypanosoma cruzi Infection Leads to Tissue-Dependent Parasite Control Natasha Perumal, Brooke White, Fernando Sanchez-Valdez, Rick L Tarleton. J Immunol. 2023 Aug 21;ji2300373. doi: 10.4049/jimmunol.2300373. Diagnosis and Treatment of a Natural Infection with Trypanosoma Cruzi (Chagas Disease) in a Symptomatic De Brazza’s Monkey (Cercopithecus Neglectus) in Alabama Stephanie McCain, Richard R Sim, Bridget Weidner, Anne E Rivas, Brooke White, Lisa D Auckland, Rick L Tarleton, Sarah Hamer. J Zoo Wildl Med. 2023 Jul;54(2):412-416. doi: 10.1638/2022-0095 Delayed Activation of T Cells at the Site of Infection Facilitates the Establishment of Trypanosoma cruzi in Both Naive and Immune Hosts Angel M Padilla, Charles Rosenberg, Peter Cook, Fernando Sanchez-Valdez, Caroline McElhannon, Rick L Tarleton. mSphere. 2023 Jan 25;e0060122. doi: 10.1128/msphere.00601-22. Epitopes in the Glycosylphosphatidylinositol Attachment Signal Peptide of Trypanosoma cruzi Mucin Proteins Generate Robust but Delayed and Nonprotective CD8+ T Cell Responses Bunkofske ME, Perumal N, White B, Strauch EM, Tarleton R. J Immunol. 2023 Feb 15;210(4):420-430. doi: 10.4049/jimmunol.2200723. PubMed PMID: 36603035; PubMed Central PMCID: PMC9898211. Prophylactic low-dose, bi-weekly benznidazole treatment fails to prevent Trypanosoma cruzi infection in dogs under intense transmission pressure Juan M Bustamante, Angel M Padilla, Brooke White, Lisa D Auckland, Rachel E Busselman, Stephanie Collins, Elizabeth L Malcolm, Briana F Wilson, Ashley B Saunders, Sarah A Hamer, Rick L Tarleton. PLoS Negl Trop Dis. 2022 Oct 31;16(10):e0010688. doi: 10.1371/journal.pntd.0010688. Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates Angel M. Padilla,Wei Wang, Tsutomu Akama, David S. Carter, Eric Easom, Yvonne Freund, Jason S. Halladay, Yang Liu, Sarah A. Hamer, Carolyn L. Hodo, Gregory K. Wilkerson, Dylan Orr, Brooke White, Arlene George, Huifeng Shen, Yiru Jin, Michael Zhuo Wang, Susanna Tse, Robert T. Jacobs & Rick L. Tarleton. Nat Microbiol (2022). https://doi.org/10.1038/s41564-022-01211-y Quantitative 3D Imaging of Trypanosoma cruzi-Infected Cells, Dormant Amastigotes, and T Cells in Intact Clarified Organs. Fernando Sanchez-Valdez, Ángel M Padilla, Juan M Bustamante, Caleb WD Hawkins, Rick L Tarleton. J Vis Exp. 2022 Jun 23;(184).doi: 10.3791/63919.PMID: 35815998 Strain-specific genome evolution in Trypanosoma cruzi, the agent of Chagas disease Wang W, Peng D, Baptista RP, Li Y, Kissinger JC, Tarleton RL (2021) Strain-specific genome evolution in Trypanosoma cruzi, the agent of Chagas disease. PLoS Pathog 17(1): e1009254. https://doi.org/10.1371/journal.ppat.1009254 A flexible, pan-species, multi-antigen platform for the detection and monitoring of SARS-CoV-2-specific antibody responses Huifeng Shen, David Forgacs, Digantkumar Chapla, Kelley W. Moremen, Lance Wells, Sarah A. Hamer, Stephen M. Tompkins, Ted M. Ross, Nadine Rouphael, Srilatha Edupuganti, Matthew H. Collins, Rick L. Tarleton medRxiv 27 Jan 2021 doi: https://doi.org/10.1101/2021.01.20.21249279 A modified drug regimen clears active and dormant trypanosomes in mouse models of Chagas disease Bustamante JM, Sanchez-Valdez F, Padilla A, White BE, Wang W, Tarleton RL. Science Translational Medicine 28 Oct 2020: Vol. 12, Issue 567, eabb7656 DOI: 10.1126/scitranslmed.abb7656 Cutting Edge: Augmenting Muscle MHC Expression Enhances Systemic Pathogen Control at the Expense of T Cell Exhaustion. Pack AD, Tarleton RL. J Immunol. 2020 Aug 1;205(3):573-578. doi: 10.4049/jimmunol.2000218. Epub 2020 Jun 26. PubMed PMID: 32591392; PubMed Central PMCID: PMC7369248. Chagas Disease Drug Discovery: Multiparametric Lead Optimization Against Trypanosoma cruzi in Acylaminobenzothiazole Series. Fleau C, Padilla A, Miguel-Siles J, Quesada-Campos MT, Saiz-Nicolas I, Cotillo I, Cantizani Perez J, Tarleton RL, Marco M, Courtemanche G. J Med Chem. 2019 Nov 27;62(22):10362-10375. doi: 10.1021/acs.jmedchem.9b01429. Epub 2019 Nov 18. Protozoan persister-like cells and drug treatment failure. Barrett MP, Kyle DE, Sibley LD, Radke JB, Tarleton RL. Nat Rev Microbiol. 2019 Oct;17(10):607-620. doi: 10.1038/s41579-019-0238-x. Epub 2019 Aug 23. Review. Drug Discovery for Kinetoplastid Diseases: Future Directions. Rao SPS, Barrett MP, Dranoff G, Faraday CJ, Gimpelewicz CR, Hailu A, Jones CL, Kelly JM, Lazdins-Helds JK, Mäser P, Mengel J, Mottram JC, Mowbray CE, Sacks DL, Scott P, Späth GF, Tarleton RL, Spector JM, Diagana TT. ACS Infect Dis. 2019 Feb 8;5(2):152-157. doi: 10.1021/acsinfecdis.8b00298. Epub 2018 Dec 13. Highly Competent, Non-Exhausted CD8+ T Cells Continue to Tightly Control Pathogen Load Throughout Chronic Trypanosoma Cruzi Infection. Pack AD, Collins MH, Rosenberg CS, Tarleton RL. PLoS Pathog. 2018 Nov 12;14(11):e1007410. doi: 10.1371/journal.ppat.1007410. eCollection 2018 Nov. Distinct Treatment Outcomes of Antiparasitic Therapy in Trypanosoma cruzi-Infected Children Is Associated With Early Changes in Cytokines, Chemokines, and T-Cell Phenotypes. Albareda MC, Natale MA, De Rissio AM, Fernandez M, Serjan A, Alvarez MG, Cooley G, Shen H, Viotti R, Bua J, Castro Eiro MD, Nuñez M, Fichera LE, Lococo B, Scollo K, Tarleton RL, Laucella SA. Front Immunol. 2018 Sep 13;9:1958. doi: 10.3389/fimmu.2018.01958. eCollection 2018. Spontaneous dormancy protects Trypanosoma cruzi during extended drug exposure. Sánchez-Valdéz FJ, Padilla A, Wang W, Orr D, Tarleton RL. Elife. 2018 Mar 26;7. pii: e34039. doi: 10.7554/eLife.34039. Engineered trivalent immunogen adjuvanted with a STING agonist confers protection against Trypanosoma cruzi infection. Sanchez Alberti A, Bivona AE, Cerny N, Schulze K, Weißmann S, Ebensen T, Morales C, Padilla AM, Cazorla SI, Tarleton RL, Guzmán CA, Malchiodi EL. NPJ Vaccines. 2017 Apr 10;2:9. doi: 10.1038/s41541-017-0010-z. eCollection 2017. Rapid, Selection-Free, High-Efficiency Genome Editing in Protozoan Parasites Using CRISPR-Cas9 Ribonucleoproteins. Soares Medeiros LC, South L, Peng D, Bustamante JM, Wang W, Bunkofske M, Perumal N, Sanchez-Valdez F, Tarleton RL. mBio. 2017 Nov 7;8(6). pii: e01788-17. doi: 10.1128/mBio.01788-17. Find Rick Tarleton Lab Plasmids
